How common is methotrexate pneumonitis? A large prospective study investigates
Identifieur interne : 001556 ( Main/Exploration ); précédent : 001555; suivant : 001557How common is methotrexate pneumonitis? A large prospective study investigates
Auteurs : Navtej Sathi [Royaume-Uni] ; Batsirai Chikura [Royaume-Uni] ; Viswanath V. Kaushik [Royaume-Uni] ; Rose Wiswell [Royaume-Uni] ; Julie K. Dawson [Royaume-Uni]Source :
- Clinical Rheumatology [ 0770-3198 ] ; 2012-01-01.
English descriptors
- KwdEn :
Abstract
Abstract: The current literature states the prevalence of methotrexate pneumonitis (MTX-P) to be 3.5–7.6%. This is based on retrospective data. Consequently, clinicians remain cautious in using methotrexate especially in patients with pre-existing lung disease. To get a true idea of the incidence of MTX-P we designed an ongoing prospective study, which is the largest to date. We recruited all patients starting low-dose methotrexate in our department, and followed them up for 2 years or until development of MTX-P. All patients had their pulmonary spirometry checked at baseline. Patients were excluded if they did not give consent for methotrexate therapy, or had a forced expiratory volume in 1 s (fev1) or full vital capacity (FVC) of less than 1 l. So far, 223 patients have been recruited of whom 223 have completed 6 months and 185 have finished 2 years of follow-up from commencing methotrexate. Only two patients developed MTX-P. This gave an incidence of one case every 192 patient years of MTX-P. The results of this ongoing prospective study suggest that MTX-P when diagnosed using Carson’s criteria and Chest HRCT scanning, does not occur as often as previously thought. Also it would appear from our data that baseline spirometry rather than full pulmonary function tests can be used routinely as an immediate screening of lung function prior to commencement of methotrexate. Interestingly the patients who developed MTX-P did not have any specific abnormalities at baseline.
Url:
DOI: 10.1007/s10067-011-1758-6
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000E49
- to stream Istex, to step Curation: 000E49
- to stream Istex, to step Checkpoint: 000532
- to stream Main, to step Merge: 001558
- to stream Main, to step Curation: 001556
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">How common is methotrexate pneumonitis? A large prospective study investigates</title>
<author><name sortKey="Sathi, Navtej" sort="Sathi, Navtej" uniqKey="Sathi N" first="Navtej" last="Sathi">Navtej Sathi</name>
</author>
<author><name sortKey="Chikura, Batsirai" sort="Chikura, Batsirai" uniqKey="Chikura B" first="Batsirai" last="Chikura">Batsirai Chikura</name>
</author>
<author><name sortKey="Kaushik, Viswanath V" sort="Kaushik, Viswanath V" uniqKey="Kaushik V" first="Viswanath V." last="Kaushik">Viswanath V. Kaushik</name>
</author>
<author><name sortKey="Wiswell, Rose" sort="Wiswell, Rose" uniqKey="Wiswell R" first="Rose" last="Wiswell">Rose Wiswell</name>
</author>
<author><name sortKey="Dawson, Julie K" sort="Dawson, Julie K" uniqKey="Dawson J" first="Julie K." last="Dawson">Julie K. Dawson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:ABEF789FE8287FFB40A7C0B38A5AEC513A3235D0</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1007/s10067-011-1758-6</idno>
<idno type="url">https://api.istex.fr/ark:/67375/VQC-T05B0LFW-M/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000E49</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E49</idno>
<idno type="wicri:Area/Istex/Curation">000E49</idno>
<idno type="wicri:Area/Istex/Checkpoint">000532</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000532</idno>
<idno type="wicri:doubleKey">0770-3198:2011:Sathi N:how:common:is</idno>
<idno type="wicri:Area/Main/Merge">001558</idno>
<idno type="wicri:Area/Main/Curation">001556</idno>
<idno type="wicri:Area/Main/Exploration">001556</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">How common is methotrexate pneumonitis? A large prospective study investigates</title>
<author><name sortKey="Sathi, Navtej" sort="Sathi, Navtej" uniqKey="Sathi N" first="Navtej" last="Sathi">Navtej Sathi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, Wrightington Hospital, Hall Lane, Appley Bridge, WN6 9EP, Wigan</wicri:regionArea>
<wicri:noRegion>Wigan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chikura, Batsirai" sort="Chikura, Batsirai" uniqKey="Chikura B" first="Batsirai" last="Chikura">Batsirai Chikura</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, Lincoln County Hospital, Greetwell Road, LN2 5QY, Lincoln, Lincolnshire</wicri:regionArea>
<wicri:noRegion>Lincolnshire</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaushik, Viswanath V" sort="Kaushik, Viswanath V" uniqKey="Kaushik V" first="Viswanath V." last="Kaushik">Viswanath V. Kaushik</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, Lincoln County Hospital, Greetwell Road, LN2 5QY, Lincoln, Lincolnshire</wicri:regionArea>
<wicri:noRegion>Lincolnshire</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wiswell, Rose" sort="Wiswell, Rose" uniqKey="Wiswell R" first="Rose" last="Wiswell">Rose Wiswell</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, St. Helens and Knowsley NHS Trust, Marshalls Cross Road, St. Helens, WA9 3DA, Merseyside</wicri:regionArea>
<wicri:noRegion>Merseyside</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dawson, Julie K" sort="Dawson, Julie K" uniqKey="Dawson J" first="Julie K." last="Dawson">Julie K. Dawson</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Rheumatology, St. Helens and Knowsley NHS Trust, Marshalls Cross Road, St. Helens, WA9 3DA, Merseyside</wicri:regionArea>
<wicri:noRegion>Merseyside</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Clinical Rheumatology</title>
<title level="j" type="sub">Journal of the International League of Associations for Rheumatology</title>
<title level="j" type="abbrev">Clin Rheumatol</title>
<idno type="ISSN">0770-3198</idno>
<idno type="eISSN">1434-9949</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>London</pubPlace>
<date type="published" when="2012-01-01">2012-01-01</date>
<biblScope unit="volume">31</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="79">79</biblScope>
<biblScope unit="page" to="83">83</biblScope>
</imprint>
<idno type="ISSN">0770-3198</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0770-3198</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Incidence</term>
<term>Methotrexate</term>
<term>Pneumonitis</term>
<term>Prevalence</term>
<term>Spirometry</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The current literature states the prevalence of methotrexate pneumonitis (MTX-P) to be 3.5–7.6%. This is based on retrospective data. Consequently, clinicians remain cautious in using methotrexate especially in patients with pre-existing lung disease. To get a true idea of the incidence of MTX-P we designed an ongoing prospective study, which is the largest to date. We recruited all patients starting low-dose methotrexate in our department, and followed them up for 2 years or until development of MTX-P. All patients had their pulmonary spirometry checked at baseline. Patients were excluded if they did not give consent for methotrexate therapy, or had a forced expiratory volume in 1 s (fev1) or full vital capacity (FVC) of less than 1 l. So far, 223 patients have been recruited of whom 223 have completed 6 months and 185 have finished 2 years of follow-up from commencing methotrexate. Only two patients developed MTX-P. This gave an incidence of one case every 192 patient years of MTX-P. The results of this ongoing prospective study suggest that MTX-P when diagnosed using Carson’s criteria and Chest HRCT scanning, does not occur as often as previously thought. Also it would appear from our data that baseline spirometry rather than full pulmonary function tests can be used routinely as an immediate screening of lung function prior to commencement of methotrexate. Interestingly the patients who developed MTX-P did not have any specific abnormalities at baseline.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Sathi, Navtej" sort="Sathi, Navtej" uniqKey="Sathi N" first="Navtej" last="Sathi">Navtej Sathi</name>
</noRegion>
<name sortKey="Chikura, Batsirai" sort="Chikura, Batsirai" uniqKey="Chikura B" first="Batsirai" last="Chikura">Batsirai Chikura</name>
<name sortKey="Dawson, Julie K" sort="Dawson, Julie K" uniqKey="Dawson J" first="Julie K." last="Dawson">Julie K. Dawson</name>
<name sortKey="Dawson, Julie K" sort="Dawson, Julie K" uniqKey="Dawson J" first="Julie K." last="Dawson">Julie K. Dawson</name>
<name sortKey="Kaushik, Viswanath V" sort="Kaushik, Viswanath V" uniqKey="Kaushik V" first="Viswanath V." last="Kaushik">Viswanath V. Kaushik</name>
<name sortKey="Wiswell, Rose" sort="Wiswell, Rose" uniqKey="Wiswell R" first="Rose" last="Wiswell">Rose Wiswell</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001556 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001556 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:ABEF789FE8287FFB40A7C0B38A5AEC513A3235D0 |texte= How common is methotrexate pneumonitis? A large prospective study investigates }}
This area was generated with Dilib version V0.6.33. |